Dimethyl Sulfone → HCID 66727152、化合物

反応式

Br[C:2]1[CH:7]=[C:6]([C:8](=[O:11])[CH2:9][CH3:10])[CH:5]=[CH:4][N:3]=1.[CH3:12][S:13](C)(=[O:15])=[O:14]>>[CH3:12][S:13]([C:2]1[CH:7]=[C:6]([C:8](=[O:11])[CH2:9][CH3:10])[CH:5]=[CH:4][N:3]=1)(=[O:15])=[O:14]

参加物

反応物 2

HCID 6213Dimethyl Sulfone

HCID 592773031-(2-Bromopyridin-4-yl)propan-1-one

生成物 1

HCID 66727152HCID 66727152、化合物

実験手順

Alternatively, (1-(2-bromopyridin-4-yl)-propan-1-one could be converted to the corresponding methyl sulfone via the above procedure to afford 1-(2-methanesulfonyl-pyridin-4-yl)-propan-1-one. 1-(2-Methanesulfonyl-pyridin-4-yl)-propan-1-one can be converted to the title compound by methods described in example 12.

出典と根拠

ORDレコード: ord-4fbb4c9708a34805a1971fcb44884a65
出典データセット: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08927550B2

反応ノート

読み込み中…