5-Bromo-2-methoxyphenol → (3S)-3-(5-Bromo-2-methoxyphenoxy)-1-methylpyrrolidine
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([OH:8])[CH:7]=1.[CH3:11][N:12]1[CH2:16][CH2:15][C@H:14](O)[CH2:13]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([CH:7]=1)[O:8][C@H:14]1[CH2:15][CH2:16][N:12]([CH3:11])[CH2:13]1参加物
3
実験手順
The title compound was prepared by the method outlined for Preparative Example 63 using 5-bromo-2-methoxy-phenol (1.00 g, 4.93 mmol) and (S)-1-methyl-pyrrolidin-3-ol (593 mg, 5.86 mmol) to afford titled compound as a colorless solid (430 mg, 30%). LC/MS (Method B) 1.17 min, [M+1]+ 286/288.
後処理
- customThe title compound was prepared by the method
出典と根拠
- ORDレコード
- ord-66bc8419a9a3432087c49c0b705dc6d2
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08927546B2
反応ノート
読み込み中…