2-Pyrimidineacetic Acid → HCID 58188942、化合物
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][C:8]([OH:10])=O.[CH2:11]([C@@H:18]1[NH:23][CH2:22][CH2:21][N:20]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26]([O:32][CH:33]([CH3:35])[CH3:34])[CH:25]=2)[CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([C@H:18]1[CH2:19][N:20]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26]([O:32][CH:33]([CH3:35])[CH3:34])[CH:25]=2)[CH2:21][CH2:22][N:23]1[C:8](=[O:10])[CH2:7][C:2]1[N:1]=[CH:6][CH:5]=[CH:4][N:3]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1参加物
3
実験手順
Prepared by the method outlined for Example 189 using pyrimidin-2-yl-acetic acid and 3 (S)-benz yl-1-(3-(1-methylethoxy)-4-methoxy-phenyl)-piperazine (Example 9, Compound 97) as starting materials. Product as an oil. LC/MS (Method B) 2.67 min, [M+1]+ 461. Potency class B.
後処理
- customPrepared by the method
- customLC/MS (Method B) 2.67 min, [M+1]+ 461
出典と根拠
- ORDレコード
- ord-e3009458c0f647459c644d61227cbc46
- 出典データセット
- uspto-grants-2015_01
- DOI