(S)-5-(3-benzylpiperazin-1-yl)-8-methoxy-2-(trifluoromethyl)quinoline → (S)-1-(2-benzyl-4-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)piperazin-1-yl)propan-2-one

HRID 1423242ノート

反応式

HRID 1423242 の反応式
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]3[C:15]=2[CH:16]=[CH:17][C:18]([C:26]([F:29])([F:28])[F:27])=[N:19]3)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClCC(=O)C>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]3[C:15]=2[CH:16]=[CH:17][C:18]([C:26]([F:29])([F:27])[F:28])=[N:19]3)[CH2:11][CH2:12][N:13]1[CH2:20][C:21](=[O:24])[CH3:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 1

HCID 58188941(S)-5-(3-benzylpiperazin-1-yl)-8-methoxy-2-(trifluoromethyl)quinoline

生成物 1

HCID 58189056(S)-1-(2-benzyl-4-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)piperazin-1-yl)propan-2-one収率 199.8%

試薬・触媒・溶媒 1

HCID 6571Chloroacetone溶媒

実験手順

Prepared using the same procedure described in Example 405 from 5-((S)-3-benzyl-piperazin-1-yl)-8-methoxy-2-trifluoromethyl-quinoline (254 mg, 0.63 mmol) and chloroacetone (60 μL), to afford the title compound as yellow solid (288 mg, 98%). LC/MS (Method B) 2.67 min, [M+1]+ 458.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-e64f366e320b438c9b90e7c479c7eaec
出典データセット
uspto-grants-2015_01
特許番号
US08927546B2

反応ノート

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