Hydrochloric Acid → Methyl (4R)-4-[(7-methoxy-2-oxo-6-vinyl-1,2-dihydroquinolin-4-yl)oxy]-L-prolinate hydrochloride

HRID 1423375ノート

反応式

HRID 1423375 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:14][C@H:15]3[CH2:19][N:18](C(OC(C)(C)C)=O)[C@H:17]([C:27]([O:29][CH3:30])=[O:28])[CH2:16]3)=[CH:8][C:9](=[O:13])[NH:10]2)=[CH:5][C:4]=1[CH:31]=[CH2:32].[ClH:33]>>[ClH:33].[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:14][C@H:15]3[CH2:19][NH:18][C@H:17]([C:27]([O:29][CH3:30])=[O:28])[CH2:16]3)=[CH:8][C:9](=[O:13])[NH:10]2)=[CH:5][C:4]=1[CH:31]=[CH2:32]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 592799081-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-oxo-6-vinyl-1,2-dihydroquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

生成物 1

HCID 86643488Methyl (4R)-4-[(7-methoxy-2-oxo-6-vinyl-1,2-dihydroquinolin-4-yl)oxy]-L-prolinate hydrochloride

実験手順

To the product from Step 3, 1-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-oxo-6-vinyl-1,2-dihydroquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate (2.02 g, 4.54 mmol) was added HCl (4M in dioxane) (22.72 ml, 91 mmol) at r.t. After 1.5 h, the solvent was removed in vacuo. The residue was taken up in Et2O and the solvent was removed in vacuo to yield 1.73 (99%) g of the title compound as a tan solid. LRMS ESI+ (M+H)+ 345.4.

後処理

  1. customthe solvent was removed in vacuo
  2. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-042f8635dd4549ccb633492c865ba8a6
出典データセット
uspto-grants-2015_01
特許番号
US08927569B2

反応ノート

読み込み中…