Danegaptide Hydrochloride → (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride monohydrate

HRID 1423862ノート

反応式

HRID 1423862 の反応式
[ClH:1].[NH2:2][CH2:3][C:4]([N:6]1[CH2:10][C@H:9]([NH:11][C:12](=[O:19])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][C@H:7]1[C:20]([OH:22])=[O:21])=[O:5]>C(O)(C)C.O>[OH2:5].[ClH:1].[NH2:2][CH2:3][C:4]([N:6]1[CH2:10][C@H:9]([NH:11][C:12](=[O:19])[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:8][C@H:7]1[C:20]([OH:22])=[O:21])=[O:5]

参加物

3

反応物 1

HCID 44563896Danegaptide Hydrochloride

生成物 1

HCID 68515358(2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride monohydrate

試薬・触媒・溶媒 1

HCID 21889133Propan-2-ol--water (1/1)溶媒

実験手順

32 mg of amorphous (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride was dissolved in three volumes of an isopropanol/water (19.5:0.5 ratio by volume) mixed solvent at room temperature. The container was left open, and the crystals that had formed were collected. The crystalline solid was dried at 40-50° C. under vacuum to give crystalline (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride monohydrate.

後処理

  1. additionmixed solvent at room temperature
  2. waitThe container was left open
  3. customthe crystals that had formed
  4. customwere collected
  5. customThe crystalline solid was dried at 40-50° C. under vacuum

出典と根拠

ORDレコード
ord-86beba2fb8d846608b7d17aec534caa4
出典データセット
uspto-grants-2015_01
特許番号
US08927590B2

反応ノート

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