HCID 86699023、化合物 → HCID 178462332、化合物
反応式
C(OC([N:8]1[C@@H:12]([C:13](O)=O)[C@@H:11]([CH3:16])[O:10]C1(C)C)=O)(C)(C)C.[NH2:19][C:20]1[CH:21]=[C:22]([C:27]2[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][CH:28]=2)[CH:23]=[CH:24][C:25]=1[NH2:26]>>[NH2:8][C@@H:12]([C:13]1[NH:26][C:25]2[CH:24]=[CH:23][C:22]([C:27]3[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][CH:28]=3)=[CH:21][C:20]=2[N:19]=1)[C@H:11]([OH:10])[CH3:16]参加物
3
実験手順
The title compound was prepared according to Method 4 using (4R,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid (Preparation 59A) and 3′,4′-diaminobiphenyl-4-carbonitrile (Preparation 82). The reaction mixture was concentrated in vacuo and purified by SCX-2 cartridge (16 mg, 72%).
後処理
- concentrationThe reaction mixture was concentrated in vacuo
- custompurified by SCX-2 cartridge (16 mg, 72%)
出典と根拠
- ORDレコード
- ord-940e6bbb6e86463baa1a7407ecb14986
- 出典データセット
- uspto-grants-2015_01
- DOI