Diethyl Ether → Methyl 3-butanoyl-4-hydroxybenzoate

HRID 14248ノート

反応式

HRID 14248 の反応式
[C:1]([CH:6]1[CH2:11][C:10](O)([C:12]([O:14][CH3:15])=[O:13])[CH:9]=[CH:8][C:7]1=[O:17])(=[O:5])[CH2:2][CH2:3][CH3:4].B(F)(F)F.O(CC)CC>C1C=CC=CC=1>[C:1]([C:6]1[CH:11]=[C:10]([CH:9]=[CH:8][C:7]=1[OH:17])[C:12]([O:14][CH3:15])=[O:13])(=[O:5])[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 6356Boron trifluorideHCID 21086214HCID 21086214、化合物

生成物 1

HCID 12533653Methyl 3-butanoyl-4-hydroxybenzoate

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a stirred solution of methyl 5-butyryl-1-hydroxy-4-oxocyclohex-2-ene-1-carboxylate in benzene was added BF3.O(Et)2 (1.3 mL, 10 mmol). The mixture was stirred for 0.25 h and then quenched with saturated sodium bicarbonate followed by extraction with dichloromethane. The organic layer was dried (sodium sulfate), filtered, and concentrated under reduced pressure to afford methyl 3-butyryl-4-hydroxybenzoate which was used without further purification or characterization.

後処理

  1. customquenched with saturated sodium bicarbonate
  2. extractionfollowed by extraction with dichloromethane
  3. dry with materialThe organic layer was dried (sodium sulfate)
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d45898382cf545c6a8d183ff834260e4
出典データセット
uspto-grants-2010_06
特許番号
US07727997B2

反応ノート

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