Methyl cis(+/-)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-2-carboxylate → Methyl cis(+/-)-4-(4-amino-3-methoxypiperidin-1-yl)pyridine-2-carboxylate

HRID 1425226ノート

反応式

HRID 1425226 の反応式
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[CH:22][N:21]=[C:20]([C:24]([O:26][CH3:27])=[O:25])[CH:19]=2)[CH2:14][C@H:13]1[O:28][CH3:29])=O)C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[CH:22][N:21]=[C:20]([C:24]([O:26][CH3:27])=[O:25])[CH:19]=2)[CH2:14][C@H:13]1[O:28][CH3:29]

参加物

5

反応物 2

HCID 86648699Methyl cis(+/-)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-2-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 86648700Methyl cis(+/-)-4-(4-amino-3-methoxypiperidin-1-yl)pyridine-2-carboxylate収率 42.7%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

Methyl cis(±)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-2-carboxylate obtained in Example (160b) (74.8 mg) was dissolved in ethanol (10 mL). A 10% palladium-carbon catalyst (100 mg) was added, and the mixture was stirred in a hydrogen atmosphere overnight. The reaction solution was filtered through celite and then concentrated under reduced pressure, to obtain 21.2 mg of the title compound as a colorless oily substance. The resulting compound was used for the next reaction without purification.

後処理

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-6c16bba8309d4869a8030030084f102d
出典データセット
uspto-grants-2015_01
特許番号
US08927588B2

反応ノート

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