Methyl cis(+/-)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate → Methyl cis(+/-)-4-(4-amino-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate

HRID 1425237ノート

反応式

HRID 1425237 の反応式
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([CH3:24])[N:21]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[CH:19]=2)[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([CH3:24])[N:21]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[CH:19]=2)[CH2:14][C@H:13]1[O:29][CH3:30]

参加物

3

反応物 1

HCID 86648714Methyl cis(+/-)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate

生成物 1

HCID 86648716Methyl cis(+/-)-4-(4-amino-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate収率 100.5%

試薬・触媒・溶媒 1

HCID 178418390HCID 178418390、化合物触媒

実験手順

The same operation as in Example (160c) was performed using methyl cis(±)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate obtained in Example (168a) (190 mg) and a 10% palladium-carbon catalyst (200 mg), to obtain 129 mg of the title compound as a colorless oily substance. The resulting compound was used for the next reaction without purification.

出典と根拠

ORDレコード
ord-a17ca590ecf04de5bd854414bbd910ae
出典データセット
uspto-grants-2015_01
特許番号
US08927588B2

反応ノート

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