HCID 131730871、化合物 → Ethyl cis(+/-)-2-(4-amino-3-methoxypiperidin-1-yl)-5-methylpyridine-4-carboxylate

HRID 1425260ノート

反応式

HRID 1425260 の反応式
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:21]([CH3:29])=[CH:20][N:19]=2)[CH2:14][C@H:13]1[O:30][CH3:31])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:21]([CH3:29])=[CH:20][N:19]=2)[CH2:14][C@H:13]1[O:30][CH3:31]

参加物

3

反応物 1

HCID 131730871HCID 131730871、化合物

生成物 1

HCID 86648743Ethyl cis(+/-)-2-(4-amino-3-methoxypiperidin-1-yl)-5-methylpyridine-4-carboxylate収率 18.5%

試薬・触媒・溶媒 1

HCID 178418390HCID 178418390、化合物触媒

実験手順

The same operation as in Example (160c) was performed using ethyl cis(±)-2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methylpyridine-4-carboxylate obtained in Example (180a) (207 mg, 0.48 mmol) and a 10% palladium-carbon catalyst (200 mg), to obtain 26.1 mg of the title compound as a yellow oily substance.

出典と根拠

ORDレコード
ord-837a38fa62fa46348d60db67ee78149f
出典データセット
uspto-grants-2015_01
特許番号
US08927588B2

反応ノート

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