7-Bromo-1-Chloroisoquinoline → 7-bromo-2-(N-propylamino)isoquinoline
反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2Cl)=[CH:4][CH:3]=1>C(N)CC>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]([NH:8][CH2:7][CH2:6][CH3:5])[CH2:9]2)=[CH:4][CH:3]=1参加物
3
実験手順
A solution of 7-bromo-1-chloroisoquinoline in propylamine (15.0 mL) was heated at 70° C. in a sealed tube overnight. The reaction mixture was concentrated under reduced pressure, then dissolved in chloroform and washed with saturated sodium bicarbonate, saturated sodium chloride, dried (sodium sulfate), filtered, and concentrated under reduced pressure to yield 7-bromo-2-(N-propylamino)isoquinoline (820 mg): ESI MS m/z 266 [M+H]+.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- dissolutiondissolved in chloroform
- washwashed with saturated sodium bicarbonate, saturated sodium chloride
- dry with materialdried (sodium sulfate)
- filtrationfiltered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-d4e7541abda242baa613fc8098349853
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07727997B2
反応ノート
読み込み中…