7-Bromo-1-Chloroisoquinoline → 7-bromo-2-(N-propylamino)isoquinoline

HRID 14256

反応式

HRID 14256 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2Cl)=[CH:4][CH:3]=1>C(N)CC>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]([NH:8][CH2:7][CH2:6][CH3:5])[CH2:9]2)=[CH:4][CH:3]=1

参加物

3

反応物 1

HCID 65020247-Bromo-1-Chloroisoquinoline

生成物 1

HCID 210859967-bromo-2-(N-propylamino)isoquinoline

試薬・触媒・溶媒 1

HCID 7852Propylamine溶媒

実験手順

A solution of 7-bromo-1-chloroisoquinoline in propylamine (15.0 mL) was heated at 70° C. in a sealed tube overnight. The reaction mixture was concentrated under reduced pressure, then dissolved in chloroform and washed with saturated sodium bicarbonate, saturated sodium chloride, dried (sodium sulfate), filtered, and concentrated under reduced pressure to yield 7-bromo-2-(N-propylamino)isoquinoline (820 mg): ESI MS m/z 266 [M+H]+.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. dissolutiondissolved in chloroform
  3. washwashed with saturated sodium bicarbonate, saturated sodium chloride
  4. dry with materialdried (sodium sulfate)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d4e7541abda242baa613fc8098349853
出典データセット
uspto-grants-2010_06
特許番号
US07727997B2

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