Water → 4-[(15-Tert-butoxycarbonylpentadecanoylamino)methyl]benzoic acid

HRID 1425664ノート

反応式

HRID 1425664 の反応式
O=C1CCC(=O)N1O[C:9](=[O:31])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25].NC[C:34]1[CH:42]=[CH:41][CH:40]=[CH:39][C:35]=1[C:36]([OH:38])=[O:37].O.[CH3:44][N:45]1C(=O)CCC1>>[C:27]([O:26][C:24]([CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9]([NH:45][CH2:44][C:41]1[CH:42]=[CH:34][C:35]([C:36]([OH:38])=[O:37])=[CH:39][CH:40]=1)=[O:31])=[O:25])([CH3:28])([CH3:29])[CH3:30]

参加物

5

反応物 4

HCID 962WaterHCID 13387N-methyl-2-pyrrolidoneHCID 2779422-Aminomethylbenzoic acidHCID 595628071-tert-Butyl 16-(2,5-dioxopyrrolidin-1-yl) hexadecanedioate

生成物 1

HCID 596879104-[(15-Tert-butoxycarbonylpentadecanoylamino)methyl]benzoic acid

実験手順

Hexadecanedioic acid tert-butyl ester 2,5-dioxo-pyrrolidin-1-yl ester (370 mg, 0.842 mmol) was dissolved in NMP (8 mL), 4 aminomethyl benzoic acid (127.2 mg, 0.842 mmol) was added, the mixture was stirred at room temperature overnight, followed by heating at for 2 hours at 50 degrees celcius. After cooling to room temperature the mixture was poured into water. Product isolated by filtration dried and used for the next step without any further purification.

後処理

  1. temperatureby heating at for 2 hours at 50 degrees celcius
  2. temperatureAfter cooling to room temperature the mixture
  3. customProduct isolated by filtration
  4. customdried
  5. customused for the next step without any further purification

出典と根拠

ORDレコード
ord-6db4a91e9a9945a5ba5a3daf9a285daa
出典データセット
uspto-grants-2015_01
特許番号
US08933021B2

反応ノート

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