2-Bromo-1-(4-hydroxymethyl-2-methyl-phenyl)-ethanone → 2-Bromo-1-[4-(1-hydroxy-ethyl)-2-methyl-phenyl]ethanone

反応式

[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][OH:12])=[CH:7][C:6]=1[CH3:13])=[O:4].O[CH:15](C1C=CC(C(=O)C)=C(C)C=1)C>>[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([OH:12])[CH3:15])=[CH:7][C:6]=1[CH3:13])=[O:4]

参加物

反応物 2

HCID 866955352-Bromo-1-(4-hydroxymethyl-2-methyl-phenyl)-ethanone

HCID 866955571-[4-(1-Hydroxy-ethyl)-2-methyl-phenyl]-ethanone

生成物 1

HCID 866955582-Bromo-1-[4-(1-hydroxy-ethyl)-2-methyl-phenyl]ethanone収率 82%

実験手順

2-Bromo-1-[4-(1-hydroxy-ethyl)-2-methyl-phenyl]ethanone is prepared following preparation 1b employing 1-[4-(1-hydroxy-ethyl)-2-methyl-phenyl]-ethanone instead of 1-(4-hydroxymethyl-2-methyl-phenyl)-ethanone.

出典と根拠

ORDレコード: ord-c67596f818ef4d568303f06b461118ff
出典データセット: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08933079B2

反応ノート

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