Ethanol → 5-(3-chloro-4-methoxyphenyl)-2,2-dimethylfuran-3(2H)-one
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:10](=[O:17])[C:11]#[C:12][C:13](O)([CH3:15])[CH3:14])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].C(NCC)C.C([OH:25])C>>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[O:17][C:13]([CH3:14])([CH3:15])[C:12](=[O:25])[CH:11]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]参加物
4
実験手順
To a stirred solution of 1-(3-chloro-4-methoxyphenyl)-4-hydroxy-4-methylpent-2-yn-1-one (0.7 g, 2.75 mmol) in ethanol (5 mL), a solution of diethyl amine (0.20 g, 2.75 mmol) in EtOH (7 mL) was added dropwise at RT. The reaction mixture was then stirred for additional 30 min. The ethanol was removed, and the reaction mixture diluted with EtOAc (10 mL). The combined organic layers were then washed with water (5 mL) and brine (5 mL), dried over Na2SO4, filtered, and concentrated in vacuo to afford 5-(3-chloro-4-methoxyphenyl)-2,2-dimethylfuran-3(2H)-one (0.7 g, 100%) as a semi solid.
後処理
- customThe ethanol was removed
- additionthe reaction mixture diluted with EtOAc (10 mL)
- washThe combined organic layers were then washed with water (5 mL) and brine (5 mL)
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-7cd363edc1644141b95d5ecbdb7f4590
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08933074B2
反応ノート
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