Dipropylamine → 7-bromo-N,N-dipropylisoquinolin-1-amine

HRID 14259

反応式

HRID 14259 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2Cl)=[CH:4][CH:3]=1.[CH2:13]([NH:16][CH2:17][CH2:18][CH3:19])[CH2:14][CH3:15]>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[N:16]([CH2:17][CH2:18][CH3:19])[CH2:13][CH2:14][CH3:15])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 8902DipropylamineHCID 65020247-Bromo-1-Chloroisoquinoline

生成物 1

HCID 210859987-bromo-N,N-dipropylisoquinolin-1-amine収率 62%

実験手順

A solution of 7-bromo-1-chloroisoquinoline from step 1 (500 mg, 2.1 mmol) and dipropylamine (2.8 mL, 21 mmol) was heated at 150° C. in a sealed tube for 2 d. The reaction mixture was cooled, and the solvent was removed under reduced pressure to provide 7-bromo-N,N-dipropylisoquinolin-1-amine (400 mg): 1H NMR (300 MHz, DMSO-d6) δ 8.55 (s, 1H), 7.90 (d, J=6 Hz, 1H), 7.75-7.64 (m, 2H), 6.87 (d, J=6 Hz, 1H), 3.42 (q, J=7 Hz, 4H), 1.65 (q, J=7 Hz, 4H), 0.94 (t, J=7 Hz, 6H).

後処理

  1. temperatureThe reaction mixture was cooled
  2. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-4b76805d6cdd4d3b993d8caf5460cb22
出典データセット
uspto-grants-2010_06
特許番号
US07727997B2

関連ノート

読み込み中…