1,2-Dibromoethane → 1-(6-Bromopyridin-2-YL)cyclopropane-1-carboxylic acid
反応式
C([O:3][C:4](=[O:13])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Br:12])[N:7]=1)C.Br[CH2:15][CH2:16]Br>>[Br:12][C:8]1[N:7]=[C:6]([C:5]2([C:4]([OH:3])=[O:13])[CH2:16][CH2:15]2)[CH:11]=[CH:10][CH:9]=1参加物
3
実験手順
The title compound was prepared from (6-bromo-pyridin-2-yl)-acetic acid ethyl ester and 1,2-dibromoethane following a procedure analogous to that described in Step 3 for Intermediate 4; under these conditions the ester group was hydrolyzed. Yield: 57% of theory; LC (method 3): tR=2.60 min; Mass spectrum (ESI+): m/z=242/244 (Br) [M+H]+.
出典と根拠
- ORDレコード
- ord-a7fac878a6ea4132bac53e71e8d2373e
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08933072B2
反応ノート
読み込み中…