反応式
[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]2[C:13]([OH:14])=[CH:12][CH:11]=[CH:10][N:9]=2)[S:5][CH:6]=1.[ClH:15].Br[CH2:17][C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1.C(=O)([O-])[O-].[K+].[K+]>>[ClH:15].[ClH:15].[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]2[C:13]([O:14][CH2:17][C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)=[CH:12][CH:11]=[CH:10][N:9]=2)[S:5][CH:6]=1参加物
4
実験手順
2-(4-Methylthiazol-2-ylamino)pyridin-3-ol (prepared according to Example 3, Step A; 75 mg, 0.362 mmol), 3-(bromomethyl)pyridine hydrochloride (75.4 mg, 0.362 mmol) and potassium carbonate (175 mg, 1.27 mmol) were reacted according to Example 3, Step B, to provide N-(4-methylthiazol-2-yl)-3-(pyridin-3-ylmethoxy)pyridin-2-amine dihydrochloride (67 mg, 49.9% yield) as a tan solid. 1H NMR (d6-DMSO) δ 10.15 (bs, 1H), 8.82 (s, 1H), 8.57 (d, 1H), 8.07 (m, 1H), 7.88 (dd, 1H), 7.46 (m, 2H), 6.92 (dd, 1H), 6.58 (s, 1H), 5.29 (s, 2H), 2.24 (s, 3H). Mass spectrum (apci) m/z=299 (M+H-2HCl).
出典と根拠
- ORDレコード
- ord-a5bd2c43341c4024a12e02224190de60
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08933077B2
関連ノート
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