Acetaldehyde → 1-(5-(Benzyloxy)-6-(4-methylthiazol-2-ylamino)pyridin-3-yl)ethanol
反応式
Cl.[CH2:2]([O:9][C:10]1[C:11]([NH:17][C:18]2[S:19][CH:20]=[C:21]([CH3:23])[N:22]=2)=[N:12][CH:13]=[C:14](Br)[CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Li]C.C([Li])CCC.[CH:31](=[O:33])[CH3:32]>>[CH2:2]([O:9][C:10]1[CH:15]=[C:14]([CH:31]([OH:33])[CH3:32])[CH:13]=[N:12][C:11]=1[NH:17][C:18]1[S:19][CH:20]=[C:21]([CH3:23])[N:22]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1参加物
5
実験手順
3-(Benzyloxy)-5-bromo-N-(4-methylthiazol-2-yl)pyridin-2-amine (prepared according to Example 1) (0.350 g, 0.930 mmol), MeLi (0.727 mL, 1.16 mmol), butyllithium (0.465 mL, 1.16 mmol), and acetaldehyde (0.0410 g, 0.930 mmol) were reacted according to the method of Example 7 to provide 1-(5-(benzyloxy)-6-(4-methylthiazol-2-ylamino)pyridin-3-yl)ethanol (0.187 g, 58.8%). Mass spectrum (apci) m/z=342.1 (M+H).
出典と根拠
- ORDレコード
- ord-47162b9577714390954d1a7960a6dc14
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08933077B2
反応ノート
読み込み中…