Phenylacetylene → 2-tert-Butyl-6-phenylethynyl-[1,2,4]triazolo[1,5-a]pyrimidine

反応式

Br[C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[N:10]=2)[CH:7]=1.[C:15]1([C:21]#[CH:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:11]([C:9]1[N:10]=[C:5]2[N:4]=[CH:3][C:2]([C:22]#[C:21][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:7][N:6]2[N:8]=1)([CH3:14])([CH3:13])[CH3:12]

参加物

反応物 2

HCID 10821Phenylacetylene

HCID 583167046-Bromo-2-tert-butyl-[1,2,4]triazolo[1,5-a]pyrimidine

生成物 1

HCID 532475712-tert-Butyl-6-phenylethynyl-[1,2,4]triazolo[1,5-a]pyrimidine

実験手順

The title compound, a yellow solid, MS: m/e=277.1 (M+H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-tert-butyl-[1,2,4]triazolo[1,5-a]pyrimidine (example 42, step 1) and phenylacetylene.

出典と根拠

ORDレコード: ord-2b110013a9c94895904ea00b41164de3
出典データセット: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08933094B2

反応ノート

読み込み中…