tert-butyl 4-(1H-pyrazol-1-yl)piperidine-1-carboxylate → 4-(1H-Pyrazol-1-yl)piperidine

HRID 1426396

反応式

HRID 1426396 の反応式
[N:1]1([CH:6]2[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[CH:5]=[CH:4][CH:3]=[N:2]1>Cl.O1CCOCC1>[N:1]1([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH:5]=[CH:4][CH:3]=[N:2]1

参加物

4

反応物 1

HCID 67971778tert-butyl 4-(1H-pyrazol-1-yl)piperidine-1-carboxylate

生成物 1

HCID 211930454-(1H-Pyrazol-1-yl)piperidine収率 96%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒

実験手順

The title compound from Step B above (50 mg, 0.2 mmol) was dissolved in 4 M HCl in dioxane (2.0 mL) and stirred at RT for 1 h. The product was concentrated under reduced pressure and dried under high vacuum to give the title compound (i-17) (30 mg, 96%). ESI-MS calculated for C8H13N3: Exact Mass: 151.11. Found 152.10.

後処理

  1. concentrationThe product was concentrated under reduced pressure
  2. customdried under high vacuum

出典と根拠

ORDレコード
ord-021c54d5a6384137b096a5b088cffd94
出典データセット
uspto-grants-2015_01
特許番号
US08933102B2

関連ノート

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