Methanol → Methyl 1-butylisoquinoline-7-carboxylate

HRID 14268

反応式

HRID 14268 の反応式
[CH2:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]([OH:17])=[O:16])[CH:13]=2)[CH:8]=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4].S(=O)(=O)(O)O.[CH3:23]O>>[CH2:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]([O:17][CH3:23])=[O:16])[CH:13]=2)[CH:8]=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 210851771-Butylisoquinoline-7-carboxylic acid

生成物 1

HCID 21086138Methyl 1-butylisoquinoline-7-carboxylate

実験手順

A solution of 1-butylisoquinoline-7-carboxylic acid (325 mg, 1.41 mmol) in methanol (25 mL) containing concentrated sulfuric acid (800 μL) was refluxed overnight. The reaction mixture was then concentrated under reduced pressure, diluted with methylene chloride, washed with water, and saturated sodium chloride. The organic layer was then dried (sodium sulfate), filtered, and concentrated to yield methyl 1-butylisoquinoline-7-carboxylate (350 mg): ESI MS m/z 244 [M+H]+;

後処理

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was then concentrated under reduced pressure
  3. additiondiluted with methylene chloride
  4. washwashed with water, and saturated sodium chloride
  5. dry with materialThe organic layer was then dried (sodium sulfate)
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-7a3169cd7e464668803ed69980273ac8
出典データセット
uspto-grants-2010_06
特許番号
US07727997B2

関連ノート

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