Isopropanol → HCID 86619830、化合物

HRID 1426872ノート

反応式

HRID 1426872 の反応式
[C:1]([O:5][C:6]1[CH:11]=[C:10]([N:12]=[C:13]=[S:14])[CH:9]=[C:8]([F:15])[CH:7]=1)([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[CH:23]([OH:26])([CH3:25])[CH3:24]>>[CH:23]([O:26][C:13](=[S:14])[NH:12][C:10]1[CH:9]=[C:8]([F:15])[CH:7]=[C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])[CH:11]=1)([CH3:25])[CH3:24]

参加物

4

反応物 3

HCID 3776IsopropanolHCID 8471TriethylamineHCID 86619831HCID 86619831、化合物

生成物 1

HCID 86619830HCID 86619830、化合物

反応条件

温度
0 °C

実験手順

1-tert-Butoxy-3-fluoro-5-isothiocyanatobenzene (24.0 g) and triethylamine (10.9 g) are dissolved in iso-propanol (150 ml). The reaction mixture is refluxed for 18 hours and the solvent is removed by vacuo. The crude product is dissolved in hexane: diethyl ether (19:1). The diethyl ether is removed in vacuo and the solution is cooled to 0° C. for 3 hours. The solution is filtered to give the title compound.

後処理

  1. temperatureThe reaction mixture is refluxed for 18 hours
  2. customthe solvent is removed by vacuo
  3. dissolutionThe crude product is dissolved in hexane: diethyl ether (19:1)
  4. customThe diethyl ether is removed in vacuo
  5. filtrationThe solution is filtered

出典と根拠

ORDレコード
ord-e9c21e0a133d41aab1374f00b10ed18f
出典データセット
uspto-grants-2015_01
特許番号
US08933108B2

反応ノート

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