Water → (R)-1-(5-tert-butoxy-2-isopropoxybenzo[d]thiazol-7-yl)-2-(1-(4-butoxyphenyl)-2-methylpropan-2-ylamino)ethanol

HRID 1426880ノート

反応式

HRID 1426880 の反応式
[C:1]([O:5][C:6]1[CH:7]=[C:8]([C@@H:19]2[CH2:21][O:20]2)[C:9]2[S:13][C:12]([O:14][CH:15]([CH3:17])[CH3:16])=[N:11][C:10]=2[CH:18]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:22]([O:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][C:34]([NH2:37])([CH3:36])[CH3:35])=[CH:29][CH:28]=1)[CH2:23][CH2:24][CH3:25].O.CC(OC)(C)C>CS(C)=O>[C:1]([O:5][C:6]1[CH:7]=[C:8]([C@@H:19]([OH:20])[CH2:21][NH:37][C:34]([CH3:35])([CH3:36])[CH2:33][C:30]2[CH:31]=[CH:32][C:27]([O:26][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:28][CH:29]=2)[C:9]2[S:13][C:12]([O:14][CH:15]([CH3:17])[CH3:16])=[N:11][C:10]=2[CH:18]=1)([CH3:3])([CH3:4])[CH3:2]

参加物

6

反応物 4

HCID 962WaterHCID 15413tert-Butyl methyl etherHCID 667439521-(4-Butoxyphenyl)-2-methylpropan-2-amineHCID 86696600(R)-5-tert-butoxy-2-isopropoxy-7-oxiranyl-benzothiazole

生成物 1

HCID 86696597(R)-1-(5-tert-butoxy-2-isopropoxybenzo[d]thiazol-7-yl)-2-(1-(4-butoxyphenyl)-2-methylpropan-2-ylamino)ethanol

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
80 °C

実験手順

(R)-5-tert-butoxy-2-isopropoxy-7-oxiranyl-benzothiazole (145 g, 471.7 mmol) and 2-(4-butoxy-phenyl)-1,1-dimethyl-ethylamine (114.8 g, 518.9 mmol) were dissolved in DMSO (850 ml). The reaction mixture was heated to 80° C. and stirred for 27 h. The mixture was then cooled to 25° C. and added to a stirred mixture of water (1500 ml) and TBME (1500 ml). The aqueous layer was separated and extracted with TBME (1000 ml). The combined organic layers were sequentially washed with water (1500 ml) and brine (1000 ml), dried with anhydrous Na2SO4. After concentration, the residue was purified by column chromatography (eluting with 10% of EtOAc in n-heptane to 33% of EtOAc in n-heptane). Solid product (R)-1-(5-tert-butoxy-2-isopropoxybenzo[d]thiazol-7-yl)-2-(1-(4-butoxyphenyl)-2-methylpropan-2-ylamino)ethanol was obtained (140 g) as off-white solid.

後処理

  1. temperatureThe mixture was then cooled to 25° C.
  2. customThe aqueous layer was separated
  3. extractionextracted with TBME (1000 ml)
  4. washThe combined organic layers were sequentially washed with water (1500 ml) and brine (1000 ml)
  5. dry with materialdried with anhydrous Na2SO4
  6. concentrationAfter concentration
  7. customthe residue was purified by column chromatography (eluting with 10% of EtOAc in n-heptane to 33% of EtOAc in n-heptane)

出典と根拠

ORDレコード
ord-a04d3363571946e6a2e9b5a298ae33e0
出典データセット
uspto-grants-2015_01
特許番号
US08933108B2

反応ノート

読み込み中…