methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate → methyl 2-(4-amino-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate

HRID 1427230ノート

反応式

HRID 1427230 の反応式
C(OC([NH:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[N:12][N:13]2[C:18]([C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=1)([CH2:23][CH3:24])[C:19]([O:21][CH3:22])=[O:20])=O)(C)(C)C>Cl.CO>[NH2:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[N:12][N:13]2[C:18]([C:25]1[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=1)([CH2:23][CH3:24])[C:19]([O:21][CH3:22])=[O:20]

参加物

3

反応物 1

HCID 70562967methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate

生成物 1

HCID 70561351methyl 2-(4-amino-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate

試薬・触媒・溶媒 1

HCID 21893726Hydrochloride methanol溶媒

実験手順

A mixture of methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate (3.0 g, 6.8 mmol), as described in Example 18 Step D, in 4 N HCl/MeOH (20 mL) was stirred at room temperature for 2 h. After removing the solvent, the residue was dissolved in ethyl acetate (80 mL), pH value adjusted to 9-10 with saturated sodium bicarbonate solution, dried over sodium sulfate, then filtered. After removing the organic solvent, the residue was used for the next step without purification. LC/MS m/z=344.1 [M+H]+.

後処理

  1. customAfter removing the solvent
  2. dissolutionthe residue was dissolved in ethyl acetate (80 mL)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customAfter removing the organic solvent
  6. customthe residue was used for the next step without purification

出典と根拠

ORDレコード
ord-e065240689d4441986da8b415d686027
出典データセット
uspto-grants-2015_01
特許番号
US08933113B2

反応ノート

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