HCID 86705063、化合物 → HCID 70561537、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:15]2[C:23]3[C:18](=[C:19]([NH:24][S:25]([CH3:28])(=[O:27])=[O:26])[CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16]2)([CH2:13][CH3:14])[C:9](=[N:11]O)[CH3:10])=[CH:4][CH:3]=1>CO.[Ni]>[NH2:11][CH:9]([C:8]([N:15]1[C:23]2[C:18](=[C:19]([NH:24][S:25]([CH3:28])(=[O:27])=[O:26])[CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16]1)([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:13][CH3:14])[CH3:10]参加物
4
実験手順
A mixture of the product from Step A (68 mg, 0.162 mmol) and Raney-Ni (1 mg) in MeOH (10 mL) was purged air three times and then backfilled with H2. The mixture was stirred at ambient temperature overnight. The suspension was filtered off and the filtrate was concentrated to afford the title compound as a colorless solid. LC/MS m/z=406.0 [M+H]+. Compound 176 was obtained by the below chiral separation conditions:
後処理
- customwas purged air three times