2-Fluoro-4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzonitrile → 2-Fluoro-4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzylamine
反応式
[F:1][C:2]1[CH:9]=[C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=2[C:19]([F:22])([F:21])[F:20])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]>N.[Ni]>[F:1][C:2]1[CH:9]=[C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=2[C:19]([F:20])([F:21])[F:22])[CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5]参加物
4
実験手順
2-fluoro-4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzonitrile (2.85 g, 9.19 mmol) was hydrogenated in 40 mL saturated methanolic ammonia solution after the addition of 300 mg of Raney nickel at ambient temperature. After the catalyst had been filtered off and the mixture evaporated down the product was obtained in a yield of 99% of theory.