Ammonia → (4-Aminomethyl-phenyl)-(4-methoxy-2-trifluoromethyl-phenyl)-amine
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][CH:11]=2)=[C:5]([C:18]([F:21])([F:20])[F:19])[CH:4]=1.N>CO.[Ni]>[NH2:15][CH2:14][C:13]1[CH:12]=[CH:11][C:10]([NH:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=2[C:18]([F:19])([F:20])[F:21])=[CH:17][CH:16]=1参加物
5
実験手順
3.7 g (12.7 mmol) of 4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzonitrile were hydrogenated in a 7N solution of ammonia in methanol (100 mL) with the addition of Raney nickel at ambient temperature. After the catalyst had been filtered off and the solvent distilled off, the crude product thus obtained was reacted further without purification.
後処理
- filtrationAfter the catalyst had been filtered off
- distillationthe solvent distilled off
出典と根拠
- ORDレコード
- ord-ba359a48b5cd4297b44ae174ad0da289
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08937073B2
反応ノート
読み込み中…