4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide → 4-[4-({[4-bromo-3-(pentafluoro-lambda6-sulfanyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][C:3]=1[S:11]([F:16])([F:15])([F:14])([F:13])[F:12].[NH2:17][C:18]1[CH:34]=[CH:33][C:21]([O:22][C:23]2[CH:28]=[CH:27][N:26]=[C:25]([C:29]([NH:31][CH3:32])=[O:30])[CH:24]=2)=[CH:20][C:19]=1[F:35]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:17][C:18]2[CH:34]=[CH:33][C:21]([O:22][C:23]3[CH:28]=[CH:27][N:26]=[C:25]([C:29]([NH:31][CH3:32])=[O:30])[CH:24]=3)=[CH:20][C:19]=2[F:35])=[O:10])=[CH:4][C:3]=1[S:11]([F:16])([F:12])([F:13])([F:14])[F:15]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
The crude 1-bromo-4-isocyanato-2-(pentafluoro-λ6-sulfanyl)benzene was dissolved in DCM (70 mL). 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide (1.75 g, 6.71 mmol, 0.8 eq) was added at room temperature under N2. The mixture was stirred at room temperature for about 30 min, a lot of solid precipitated. DCM (30 mL) was added and made the mixture stirred at room temperature for 18 hrs. The solid was collected by filtration, washed with DCM (50 mL), and dried under high vacuum to afford 2.9 g of the title compound as a white solid.