Water → 2-Bromo-1-(4-fluoro-3-methylphenyl)ethanone

HRID 1428938ノート

反応式

HRID 1428938 の反応式
[Br:1]Br.[CH3:3][C:4]1[CH:9]=[C:8]([C:10]([CH3:12])=[O:11])[CH:7]=[CH:6][C:5]=1[F:13].O>C(O)(=O)C>[Br:1][CH2:12][C:10]([C:8]1[CH:7]=[CH:6][C:5]([F:13])=[C:4]([CH3:3])[CH:9]=1)=[O:11]

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 2893281-(4-Fluoro-3-methylphenyl)ethan-1-one

生成物 1

HCID 109773012-Bromo-1-(4-fluoro-3-methylphenyl)ethanone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

5.1 mL bromine was added to 15 g 4-fluor-3-methylacetophenone in 80 mL concentrated acetic acid. The reaction was stirred 3 h at RT. The reaction was added to water. The precipitate was filtered and dried to give 20.6 g desired product. Rt: 1.37 min (method I), (M+H)+: 231

後処理

  1. filtrationThe precipitate was filtered
  2. customdried

出典と根拠

ORDレコード
ord-6e9b797b55e141d3830feb44f6dcd136
出典データセット
uspto-grants-2015_01
特許番号
US08937176B2

反応ノート

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