Triethylamine → HCID 86688147、化合物

HRID 1428943ノート

反応式

HRID 1428943 の反応式
[CH2:1]([O:8][CH2:9][C:10](Cl)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH2:14]([NH:16][CH2:17][C:18]([C:20]1[CH:25]=[CH:24][C:23]([F:26])=[C:22]([CH3:27])[CH:21]=1)=[O:19])[CH3:15].C(N(CC)CC)C>ClCCl>[CH2:1]([O:8][CH2:9][C:10]([N:16]([CH2:14][CH3:15])[CH2:17][C:18]([C:20]1[CH:25]=[CH:24][C:23]([F:26])=[C:22]([CH3:27])[CH:21]=1)=[O:19])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 177085Benzyloxyacetyl chlorideHCID 866881482-Ethylamino-1-(4-fluoro-3-methyl-phenyl)-ethanone hydrochloride

生成物 1

HCID 86688147HCID 86688147、化合物収率 96.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

2.9 g benzyloxy-acetyl chloride was added to 3.7 g 2-ethylamino-1-(4-fluoro-3-methyl-phenyl)-ethanone hydrochloride and 5 mL triethylamine in 40 mL dichlormethane. The reaction was stirred 3 h at RT. The reaction was diluted with dichlormethane, washed with water, 1 mol/L aqueous hydrochloride acid and with 5% aqueous potassium carbonate solution. The organic layer was dried and evaporated to yield 5.2 g of the desired product. Rt: 0.91 min (method J), (M+H)+: 344

後処理

  1. washwashed with water, 1 mol/L aqueous hydrochloride acid and with 5% aqueous potassium carbonate solution
  2. customThe organic layer was dried
  3. customevaporated

出典と根拠

ORDレコード
ord-91be0cb77ec84453afc77e5553f10849
出典データセット
uspto-grants-2015_01
特許番号
US08937176B2

反応ノート

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