Ammonium Acetate → HCID 86688149、化合物

HRID 1428944ノート

反応式

HRID 1428944 の反応式
[CH2:1]([O:8][CH2:9][C:10]([N:12]([CH2:24][CH3:25])[CH2:13][C:14]([C:16]1[CH:21]=[CH:20][C:19]([F:22])=[C:18]([CH3:23])[CH:17]=1)=O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])(=O)C.[NH4+:30]>ClCCl>[CH2:1]([O:8][CH2:9][C:10]1[N:12]([CH2:24][CH3:25])[CH:13]=[C:14]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[C:18]([CH3:23])[CH:17]=2)[N:30]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 517165Ammonium AcetateHCID 86688147HCID 86688147、化合物

生成物 1

HCID 86688149HCID 86688149、化合物収率 74.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

5.8 g 2-benzyloxy-N-ethyl-N-[2-(4-fluoro-3-methyl-phenyl)-2-oxo-ethyl]-acetamide and 4 g ammonium acetate was melted at 200° C. for 30 min Dichlormethane was added and the mixture was washed with aqueous potassiumhydrogen carbonate solution. The organic layer was evaporated. The residue was purified by chromatographie on silica gel (cyclohexane/ethyl acetate 4:1) to yield 4.1 g of the desired product. Rt: 0.74 min (method J), (M+H)+: 325

後処理

  1. customfor 30 min
  2. additionwas added
  3. washthe mixture was washed with aqueous potassiumhydrogen carbonate solution
  4. customThe organic layer was evaporated
  5. customThe residue was purified by chromatographie on silica gel (cyclohexane/ethyl acetate 4:1)

出典と根拠

ORDレコード
ord-8daea9d4e22d48eb8921d82f9d79a469
出典データセット
uspto-grants-2015_01
特許番号
US08937176B2

反応ノート

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