Potassium Carbonate → (R)-4-Allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine
反応式
Br[CH2:2][C:3]1[CH:16]=[CH:15][CH:14]=[CH:13][C:4]=1[CH2:5][O:6][CH2:7][C@H:8]([NH2:12])[CH2:9][CH:10]=[CH2:11].C([O-])([O-])=O.[K+].[K+]>CCO>[CH2:9]([C@H:8]1[NH:12][CH2:2][C:3]2[CH:16]=[CH:15][CH:14]=[CH:13][C:4]=2[CH2:5][O:6][CH2:7]1)[CH:10]=[CH2:11]参加物
4
実験手順
To a solution of compound 18k (2.0 g, 7.0 mmol) in EtOH (20 mL) was added K2CO3 (4.8 g, 35.0 mmol) portionwise. The mixture was heated to reflux for 2 h to complete the reaction. The reaction mixture was cooled down to rt and concentrated under reduced pressure to give compound 18l (1.2 g, 84% yield), which was used without purification. LCMS (m/z): 204.1 (MH+).
後処理
- temperatureThe mixture was heated
- temperatureto reflux for 2 h
- customthe reaction
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-f36a4fd96e3f441ba28d122276245a65
- 出典データセット
- uspto-grants-2015_01
- 特許番号
- US08940722B2
反応ノート
読み込み中…