Water → 8-(Benzyloxy)-2-methoxyquinoline

HRID 1429506ノート

反応式

HRID 1429506 の反応式
[CH3:1][O:2][Na].[CH2:4]([O:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:21]=1[N:20]=[C:19](Cl)[CH:18]=[CH:17]2)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.O>CO>[CH2:4]([O:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:21]=1[N:20]=[C:19]([O:2][CH3:1])[CH:18]=[CH:17]2)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 220422348-(Benzyloxy)-2-chloroquinolineHCID 178418582HCID 178418582、化合物

生成物 1

HCID 673664878-(Benzyloxy)-2-methoxyquinoline収率 79%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
70 °C

実験手順

To a solution of MeONa (400 mg, 7.43 mmol) in MeOH (20 mL) was added 8-(benzyloxy)-2-chloroquinoline (2.0 g, 7.43 mmol). The mixture was stirred at 70° C. for 16 h. To the mixture was added H2O (20 mL) and the product extracted with toluene (30 mL×3). The combined organic layers were dried with Na2SO4 and evaporated to give the desired compound (1.5 g, yield 79%). LCMS (m/z): 266.1 [M+H]+

後処理

  1. extractionthe product extracted with toluene (30 mL×3)
  2. dry with materialThe combined organic layers were dried with Na2SO4
  3. customevaporated

出典と根拠

ORDレコード
ord-46fc35f773244243955275101c310fee
出典データセット
uspto-grants-2015_01
特許番号
US08940726B2

反応ノート

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