HCID 59805850、化合物 → HCID 23218604、化合物

HRID 1429660ノート

反応式

HRID 1429660 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[CH2:5][N:6]1[CH2:15][CH2:14][C:9]2(OCC[O:10]2)[CH2:8][CH2:7]1>Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[CH2:5][N:6]1[CH2:7][CH2:8][C:9](=[O:10])[CH2:14][CH2:15]1

参加物

3

反応物 1

HCID 59805850HCID 59805850、化合物

生成物 1

HCID 23218604HCID 23218604、化合物収率 82%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of D3 (7.9 g, 29.4 mmol) in hydrochloric acid (5N, 150 ml) was heated at 50° C. for 2 h. After this period, the reaction mixture was washed with diisopropyl ether (100 ml) and then a saturated solution of sodium hydrogen carbonate (100 ml). The mixture was then extracted with dichloromethane and the extracts dried (MgSO4) and the solvents evaporated in vacuo to give D4 (5.4 g, 82%). C12H13F2NO requires 225; Found 226 (MH+)

後処理

  1. waitAfter this period
  2. washthe reaction mixture was washed with diisopropyl ether (100 ml)
  3. extractionThe mixture was then extracted with dichloromethane
  4. dry with materialthe extracts dried (MgSO4)
  5. customthe solvents evaporated in vacuo

出典と根拠

ORDレコード
ord-ccfb022391a645d6a65c2d2295802ece
出典データセット
uspto-grants-2015_01
特許番号
US08940743B2

反応ノート

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