化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Ethyl 1-morpholinocyclohexanecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Bis(2-bromoethyl) ether | HCID 21521 | — |
| 反応物 | Ethyl 1-aminocyclohexane-1-carboxylate hydrochloride | HCID 11241228 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Ethyl 1-morpholinocyclohexanecarboxylate | HCID 86681323 | — |
反応手順
Ethyl 1-aminocyclohexancarboxylate hydrogen chloride (5.800 g), triethylamine (13.62 mL) and 1-bromo-2-(2-bromoethoxy)ethane (4.21 mL) were stirred together in N,N-dimethylformamide (50 mL) at 95° C. overnight. The reaction mixture was diluted with ethyl acetate (150 mL), washed with water (100 mL) and brine (100 mL), dried over magnesium sulfate, filtered, and concentrated. Silica gel chromatography eluting with a gradient of 5% to 25% ethyl acetate/hexanes provided the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08940737B2 |
| 出典データセット | uspto-grants-2015_01 |
| ORD ID | ord-fb5412b24ac84b32bf114eacb4a68bbe |
| 出典メモ | uspto-grants-2015_01 |