Methylamine → 5-fluoro-N-methyl-2-nitroaniline

HRID 1430399ノート

反応式

HRID 1430399 の反応式
[CH3:1][NH2:2].F[C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[N+:11]([O-:13])=[O:12]>CO>[F:10][C:8]1[CH:7]=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4]([CH:9]=1)[NH:2][CH3:1]

参加物

4

反応物 2

HCID 6329MethylamineHCID 679672,4-Difluoronitrobenzene

生成物 1

HCID 229057745-fluoro-N-methyl-2-nitroaniline収率 95%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

An aqueous solution of 40% methyl amine (61 mL, 0.71 mol) was added dropwise to a methanol solution (200 mL) of 2,4-difluoronitrobenzene (46.7 g, 0.29 mol) under ice cooling, and the mixture was stirred for 1 hour under the same temperature. The reaction solution was poured into ice water. Precipitated crystals were collected by filtration, followed by washing with water. The resulting crystals were dried at 50° C., thereby obtaining 47.6 g of a yellow, powdery target compound (yield: 95%).

後処理

  1. customPrecipitated crystals
  2. filtrationwere collected by filtration
  3. washby washing with water
  4. customThe resulting crystals were dried at 50° C.

出典と根拠

ORDレコード
ord-2bd870b8d0c641ecb21d08a7c687a969
出典データセット
uspto-grants-2015_01
特許番号
US08940889B2

反応ノート

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