Acetic Acid → 2-Amino-4-(4-morpholinyl)benzonitrile

HRID 1431290ノート

反応式

HRID 1431290 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[C:9]([N+:15]([O-])=O)[CH:8]=2)[CH2:3][CH2:2]1.C(O)(=O)C>[Zn]>[NH2:15][C:9]1[CH:8]=[C:7]([N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)[CH:14]=[CH:13][C:10]=1[C:11]#[N:12]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 134992654-Morpholino-2-nitrobenzonitrile

生成物 1

HCID 134992832-Amino-4-(4-morpholinyl)benzonitrile

試薬・触媒・溶媒 1

HCID 23994Zinc触媒

実験手順

To a mixture of 4-morpholino-2-nitrobenzonitrile (388 mg, 1664 μmol) in acetic acid (6.00 mL, 104809 μmol) at rt was added all at once zinc powder (1632 mg, 24955 μmol). An exotherm developed. The reaction was stirred at ambient temperature for 2 h then filtered, and rinsed with EtOAc. The filtrate was concd under reduced pressure to afford a slightly yellow solid. Mass Spectrum (ESI) m/e=204.1 (M+1).

後処理

  1. filtrationthen filtered
  2. washrinsed with EtOAc
  3. customto afford a slightly yellow solid

出典と根拠

ORDレコード
ord-6f4a4057ac604783850ee04112a798f7
出典データセット
uspto-grants-2015_01
特許番号
US08940724B2

反応ノート

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