2,5-Dimorpholinopyridin-3-amine → N-(2,5-di-4-morpholinyl-3-pyridinyl)-7-fluoro-3-(1-methylethyl)-2-(2-pyridinyl)-4-quinolinamine

HRID 1431430

反応式

HRID 1431430 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[C:3]=1[CH:19]([CH3:21])[CH3:20].[O:22]1[CH2:27][CH2:26][N:25]([C:28]2[C:33]([NH2:34])=[CH:32][C:31]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)=[CH:30][N:29]=2)[CH2:24][CH2:23]1>C1(C)C=CC=CC=1>[N:25]1([C:28]2[C:33]([NH:34][C:2]3[C:11]4[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=4)[N:5]=[C:4]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=4)[C:3]=3[CH:19]([CH3:21])[CH3:20])=[CH:32][C:31]([N:35]3[CH2:36][CH2:37][O:38][CH2:39][CH2:40]3)=[CH:30][N:29]=2)[CH2:24][CH2:23][O:22][CH2:27][CH2:26]1

参加物

4

反応物 2

HCID 596310462,5-Dimorpholinopyridin-3-amineHCID 596313734-Chloro-7-fluoro-3-isopropyl-2-(pyridin-2-yl)quinoline

生成物 1

HCID 59631479N-(2,5-di-4-morpholinyl-3-pyridinyl)-7-fluoro-3-(1-methylethyl)-2-(2-pyridinyl)-4-quinolinamine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Prepared according to Procedure H using 4-chloro-7-fluoro-3-isopropyl-2-(pyridin-2-yl)quinoline (45.0 mg, 0.150 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give N-(2,5-di-4-morpholinyl-3-pyridinyl)-7-fluoro-3-(1-methylethyl)-2-(2-pyridinyl)-4-quinolinamine. 1H NMR (400 MHz, chloroform-d) δ ppm 8.73 (1H, ddd, J=4.8, 1.7, 0.9 Hz), 7.88 (1H, td, J=7.7, 1.9 Hz), 7.72-7.79 (2H, m), 7.67 (1H, dt, J=7.8, 1.0 Hz), 7.58 (1H, d, J=2.7 Hz), 7.39 (1H, ddd, J=7.4, 4.9, 1.2 Hz), 7.23 (1H, ddd, J=9.4, 8.0, 2.5 Hz), 7.13 (1H, s), 6.11 (1H, d, J=2.5 Hz), 3.83-4.04 (4H, m), 3.67-3.79 (4H, m), 3.49 (2H, ddd, J=12.0, 6.3, 2.6 Hz), 3.25-3.42 (1H, m), 2.97 (2H, ddd, J=11.9, 6.2, 2.6 Hz), 2.85 (4H, t, J=4.8 Hz), 1.52 (3H, d, J=7.2 Hz), 1.12 (3H, d, J=7.0 Hz). Mass Spectrum (ESI) m/e=529.3 (M+1).

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-709209c9969e43f08e92d35e30d80eba
出典データセット
uspto-grants-2015_01
特許番号
US08940724B2

関連ノート

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