5-Morpholinopyridin-3-amine → 7-fluoro-3-(1-methylethyl)-N-(5-(4-morpholinyl)-3-pyridinyl)-2-(2-pyridinyl)-4-quinolinamine

HRID 1431431

反応式

HRID 1431431 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[C:3]=1[CH:19]([CH3:21])[CH3:20].[O:22]1[CH2:27][CH2:26][N:25]([C:28]2[CH:29]=[C:30]([NH2:34])[CH:31]=[N:32][CH:33]=2)[CH2:24][CH2:23]1>C1(C)C=CC=CC=1>[F:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:34][C:30]3[CH:31]=[N:32][CH:33]=[C:28]([N:25]4[CH2:26][CH2:27][O:22][CH2:23][CH2:24]4)[CH:29]=3)=[C:3]([CH:19]([CH3:21])[CH3:20])[C:4]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)=[N:5]2)=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 583477375-Morpholinopyridin-3-amineHCID 596313734-Chloro-7-fluoro-3-isopropyl-2-(pyridin-2-yl)quinoline

生成物 1

HCID 596313647-fluoro-3-(1-methylethyl)-N-(5-(4-morpholinyl)-3-pyridinyl)-2-(2-pyridinyl)-4-quinolinamine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Prepared according to Procedure H using 4-chloro-7-fluoro-3-isopropyl-2-(pyridin-2-yl)quinoline (45.0 mg, 0.150 mmol) and 5-morpholinopyridin-3-amine in toluene to give 7-fluoro-3-(1-methylethyl)-N-(5-(4-morpholinyl)-3-pyridinyl)-2-(2-pyridinyl)-4-quinolinamine. 1H NMR (400 MHz, chloroform-d) δ ppm 8.69-8.76 (1H, m), 7.84-7.92 (2H, m), 7.71-7.83 (3H, m), 7.68 (1H, d, J=7.8 Hz), 7.39 (1H, ddd, J=7.6, 4.9, 1.2 Hz), 7.18 (1H, ddd, J=9.2, 8.1, 2.6 Hz), 6.25 (1H, t, J=2.3 Hz), 6.03 (1H, s), 3.71-3.83 (4H, m), 3.33-3.43 (1H, m), 2.95-3.08 (4H, m), 1.32 (6H, d, J=7.2 Hz). Mass Spectrum (ESI) m/e=444.2 (M+1).

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-86863935276c4ab086c28497df98096e
出典データセット
uspto-grants-2015_01
特許番号
US08940724B2

関連ノート

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