4-Methyl-2-(tributylstannyl)pyridine → 4,8-Dichloro-3-methyl-2-(4-methylpyridin-2-yl)quinoline

HRID 1431535ノート

反応式

HRID 1431535 の反応式
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[C:5]([Cl:14])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:15][C:16]1[CH:21]=[CH:20][N:19]=[C:18]([Sn](CCCC)(CCCC)CCCC)[CH:17]=1>C1(C)C=CC=CC=1>[Cl:13][C:10]1[C:9]2[C:4](=[C:5]([Cl:14])[CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([C:18]2[CH:17]=[C:16]([CH3:15])[CH:21]=[CH:20][N:19]=2)[C:11]=1[CH3:12]

参加物

4

反応物 2

HCID 112227754-Methyl-2-(tributylstannyl)pyridineHCID 596312172,4,8-Trichloro-3-methylquinoline

生成物 1

HCID 596311454,8-Dichloro-3-methyl-2-(4-methylpyridin-2-yl)quinoline

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

The Stille coupled product was prepared according to Procedure E using 2,4,8-trichloro-3-methylquinoline (0.15 g, 0.61 mmol), 4-methyl-2-(tributylstannyl)-pyridine (0.26 g, 0.67 mmol), palladium tetrakistriphenylphosphine (0.070 g, 0.06 mmol) in toluene (1.2 mL) to give 4,8-dichloro-3-methyl-2-(4-methylpyridin-2-yl)quinoline as a light yellow solid. Mass Spectrum (ESI) m/e=303.0 (M+1).

後処理

  1. customwas prepared

出典と根拠

ORDレコード
ord-89f1b9ca576c4a0aacb2a882151f6414
出典データセット
uspto-grants-2015_01
特許番号
US08940724B2

反応ノート

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