4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid → 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)cyclohexanecarboxylic acid
反応式
[CH:1]1[N:2]=[CH:3][N:4]2[CH:9]([C:10]3[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=3)[CH2:8][CH2:7][CH2:6][C:5]=12>C(O)(=O)C>[CH:1]1[N:2]=[CH:3][N:4]2[CH:9]([CH:10]3[CH2:18][CH2:17][CH:13]([C:14]([OH:16])=[O:15])[CH2:12][CH2:11]3)[CH2:8][CH2:7][CH2:6][C:5]=12参加物
3
実験手順
A solution of 1.5 g of 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzoic acid [93178-73-5] in 5 ml of acetic acid is hydrogenated (50 bar) in the presence 0.05 g of Nishimura catalyst at room temperature. The reaction mixture is clarified by filtration, and the filtrate is evaporated. The crude title compound is obtained from the residue.
後処理
- customat room temperature
- filtrationThe reaction mixture is clarified by filtration
- customthe filtrate is evaporated
出典と根拠
- ORDレコード
- ord-a27286a4082a44739535500fd007e9f0
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07612088B2
反応ノート
読み込み中…