Benzaldehyde → N-(2-{2-[(4-Hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-phenyl-methyl]-1H-indol-3-yl}-ethyl)-benzamide

HRID 1432446

反応式

HRID 1432446 の反応式
[OH:1][C:2]1[CH:6]([CH:7]([CH3:9])[CH3:8])[NH:5][C:4](=[O:10])[CH:3]=1.[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[NH:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([CH2:28][CH2:29][NH:30][C:31](=[O:38])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[CH:20]1>>[OH:1][C:2]1[CH:6]([CH:7]([CH3:9])[CH3:8])[NH:5][C:4](=[O:10])[C:3]=1[CH:11]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:20]1[NH:19][C:27]2[C:22]([C:21]=1[CH2:28][CH2:29][NH:30][C:31](=[O:38])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[CH:23][CH:24]=[CH:25][CH:26]=2

参加物

4

反応物 3

HCID 240BenzaldehydeHCID 684658N-(2-(1H-indol-3-yl)ethyl)benzamideHCID 566041114-Hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one

生成物 1

HCID 57933477N-(2-{2-[(4-Hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-phenyl-methyl]-1H-indol-3-yl}-ethyl)-benzamide

実験手順

Using general procedure C, 4-hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one (Lit. 11) was reacted with benzaldehyde and N-[2-(1H-indol-3-yl)-ethyl]-benzamide to give the title compound as a grey solid. MS: 494.3 ([M+H]+).

出典と根拠

ORDレコード
ord-f2d04eca26d342a29e50d8e5a0668bc8
出典データセット
uspto-grants-2009_11
特許番号
US07612099B2

関連ノート

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