Acetic Anhydride → N-[2-(6-Fluoro-1H-indol-3-yl)-ethyl]-acetamide
反応式
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH2:11][CH2:12][NH2:13])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.CCN(CC)CC.[C:21](OC(=O)C)(=[O:23])[CH3:22]>C(Cl)Cl>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH2:11][CH2:12][NH:13][C:21](=[O:23])[CH3:22])=[CH:7][NH:8]2)=[CH:4][CH:3]=1参加物
5
実験手順
To a solution of 2-(6-fluoro-1H-indol-3-yl)-ethylamine (0.88 g) and NEt3 (2.27 ml) in CH2Cl2 (8 ml) was added acetic acid anhydride (0.43 ml) and stirring was continued at 22° C. for 1 h. The mixture was washed with 1 N aqueous HCl, the organic layer was dried and evaporated. The residue was chromatographed on silica using CH2Cl2/MeOH (25:1) to give the title compound as a pale yellow oil. MS: 219.1 ([M−H]−).
後処理
- washThe mixture was washed with 1 N aqueous HCl
- customthe organic layer was dried
- customevaporated
- customThe residue was chromatographed on silica
出典と根拠
- ORDレコード
- ord-432ce235113849a9b02b18ec2bd39310
- 出典データセット
- uspto-grants-2009_11
- 特許番号
- US07612099B2
反応ノート
読み込み中…