Resorcinol → 4-Cyclohexylresorcinol

HRID 1432512ノート

反応式

HRID 1432512 の反応式
[C:1]1([CH:8]=[CH:7][CH:6]=[C:4]([OH:5])[CH:3]=1)[OH:2].[CH:9]1(O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>C(OCC)(=O)C.[Cl-].[Zn+2].[Cl-]>[CH:9]1([C:6]2[CH:7]=[CH:8][C:1]([OH:2])=[CH:3][C:4]=2[OH:5])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

参加物

5

反応物 2

HCID 5054ResorcinolHCID 7966Cyclohexanol

生成物 1

HCID 750554-Cyclohexylresorcinol収率 156%

試薬・触媒・溶媒 2

HCID 3007855Zincchloride触媒HCID 8857Ethyl Acetate溶媒

実験手順

Resorcinol (2.2 g, 0.02 moles) was mixed with cyclohexanol (1 g, 0.01 moles) and zinc (II) chloride (0.48 g, 0.0035 moles) and the reaction mixture heated to 150° with stirring. After heating 2 hours, the reaction mixture was allowed to cool and then dissolved in ethyl acetate. Washed with water and dried over anhydrous magnesium sulphate. The solvent was evaporated to give a brown oil (3.0 g). Excess resorcinol was evaporated by heating in a Kugelrohr oven under reduced pressure (200°, 2 mmHg). Purified using a silica column eluted with ethyl acetate:isohexane 2:8 to give the product as a yellow oil (0.5 g). Trituration with isohexane gave the product as a white solid (0.2 g).

後処理

  1. temperaturethe reaction mixture heated to 150°
  2. temperatureAfter heating 2 hours
  3. temperatureto cool
  4. washWashed with water
  5. dry with materialdried over anhydrous magnesium sulphate
  6. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-42b3919d8d7546d7a5d86c5f878ba2bb
出典データセット
uspto-grants-2009_11
特許番号
US07612101B2

反応ノート

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