Dimethylformamide → 2-Ethoxy-n-[5-(5-isopropyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-indan-2-yl]-4-trifluoromethyl-benzamide

HRID 1432535

反応式

Cl.[CH:2]([C:5]1[S:9][C:8]([NH:10][S:11]([C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[CH2:19][CH:18]([NH2:23])[CH2:17]3)(=[O:13])=[O:12])=[N:7][N:6]=1)([CH3:4])[CH3:3].CN(C)C=O.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH2:53]([O:55][C:56]1[CH:64]=[C:63]([C:65]([F:68])([F:67])[F:66])[CH:62]=[CH:61][C:57]=1[C:58](O)=[O:59])[CH3:54]>C(N(CC)CC)C>[CH2:53]([O:55][C:56]1[CH:64]=[C:63]([C:65]([F:66])([F:67])[F:68])[CH:62]=[CH:61][C:57]=1[C:58]([NH:23][CH:18]1[CH2:17][C:16]2[C:20](=[CH:21][CH:22]=[C:14]([S:11](=[O:13])(=[O:12])[NH:10][C:8]3[S:9][C:5]([CH:2]([CH3:4])[CH3:3])=[N:6][N:7]=3)[CH:15]=2)[CH2:19]1)=[O:59])[CH3:54]

参加物

実験手順

The mixture of 2-amino-indan-5-sulfonic acid (5-isopropyl-[1,3,4]thiadiazol-2-yl)-amide hydrochloride (40 mg), 1.5 ml of dimethyl formamide, 0.037 ml of triethylamine, 41 mg of HATU and 25 mg of 2-ethoxi-4-trifluoromethyl-benzoic acid was stirred at room temperature over night. The solvents were evaporated in vacuo and the resulting crude material was purified by column chromatography (silica gel, eluent: dichloromethane:methanol=95:5).

後処理

customThe solvents were evaporated in vacuo
customthe resulting crude material was purified by column chromatography (silica gel, eluent: dichloromethane:methanol=95:5)

出典と根拠

ORDレコード: ord-cfa2d48d16724dedaaf63f4a6216ba24
出典データセット: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07612104B2

反応式

参加物

反応物 4

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

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