1,2-Dichloroethane → N-[4-(3-oxazolidinylcarbonyl)phenyl]-2N-(4-chlorophenylaminocarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

HRID 1432544ノート

反応式

HRID 1432544 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([CH:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][CH:13](C(O)=O)[NH:12]2)=[O:10])=[CH:4][CH:3]=1.[O:24]1[CH2:28][CH2:27][N:26]([C:29](C2C=CC(N)=CC=2)=[O:30])[CH2:25]1.[CH2:38]([Cl:41])[CH2:39]Cl>CN(C=O)C>[O:24]1[CH2:28][CH2:27][N:26]([C:29]([C:2]2[CH:3]=[CH:4][C:5]([NH:8][C:9]([CH:11]3[CH2:20][C:15]4[C:14](=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH2:13][N:12]3[C:9]([NH:8][C:5]3[CH:6]=[CH:39][C:38]([Cl:41])=[CH:3][CH:4]=3)=[O:10])=[O:10])=[CH:6][CH:7]=2)=[O:30])[CH2:25]1

参加物

5

反応物 3

HCID 111,2-DichloroethaneHCID 686942914-(3-Oxazolidinylcarbonyl)phenylamineHCID 131727716(4-Chlorophenylaminocarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

生成物 1

HCID 11519028N-[4-(3-oxazolidinylcarbonyl)phenyl]-2N-(4-chlorophenylaminocarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide収率 68.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 2N-(4-chlorophenylaminocarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (50 mg, 0.15 mmol) and 4-(3-oxazolidinylcarbonyl)phenylamine (25 mg, 0.13 mmol) in DMF (3 mL), EDC (75 mg, 0.39 mmol) was added. The reaction mixture was stirred at room temperature overnight. It was then concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a white powder (26 mg). MS 505.2 and 507.2 (M+H, Cl pattern).

後処理

  1. concentrationIt was then concentrated in vacuo
  2. customThe residue was purified by HPLC

出典と根拠

ORDレコード
ord-06c1883e09cd4cef91389c8966ec0a9d
出典データセット
uspto-grants-2009_11
特許番号
US07612089B2

反応ノート

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