1,2-Dichloroethane → N-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]-5N-(4-chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxamide

HRID 1432552ノート

反応式

HRID 1432552 の反応式
ClC1C=CC(NC([C:11]2[S:19][C:18]3[CH2:17][CH:16]([C:20]([OH:22])=O)[NH:15][CH2:14][C:13]=3[CH:12]=2)=O)=CC=1.[CH3:23][N:24]1[CH2:28][CH2:27][N:26]=[C:25]1[C:29]1[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][CH:30]=1.[CH2:36]([Cl:39])[CH2:37]Cl.[OH2:40]>CN(C=O)C>[CH3:23][N:24]1[CH2:28][CH2:27][N:26]=[C:25]1[C:29]1[CH:34]=[CH:33][C:32]([NH:35][C:20]([CH:16]2[N:15]([C:14]([NH:15][C:16]3[CH:20]=[CH:37][C:36]([Cl:39])=[CH:18][CH:17]=3)=[O:40])[CH2:14][C:13]3[CH:12]=[CH:11][S:19][C:18]=3[CH2:17]2)=[O:22])=[CH:31][CH:30]=1

参加物

6

反応物 4

HCID 111,2-DichloroethaneHCID 962WaterHCID 227288764-(1-Methyl-4,5-dihydro-1H-imidazol-2-yl)-phenylamineHCID 131727718(4-Chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxylic acid

生成物 1

HCID 11526092N-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]-5N-(4-chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 5N-(4-chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxylic acid (40 mg, 0.12 mmol) and 4-(1-Methyl-4,5-dihydro-1H-imidazol-2-yl)-phenylamine (42 mg, 0.24 mmol) in DMF (3 mL) and H2O (0.5 mL) at room temperature, EDC (68 mg, 0.35 mmol) was added. The mixture was stirred at room temperature overnight. It was concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a powder (25 mg). MS 494.3 and 496.3 (M+H, Cl pattern).

後処理

  1. concentrationIt was concentrated in vacuo
  2. customThe residue was purified by HPLC

出典と根拠

ORDレコード
ord-cfea6a67daa64563ab23c6c906a058a3
出典データセット
uspto-grants-2009_11
特許番号
US07612089B2

反応ノート

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