69193-39-1 → HCID 54335788、化合物

HRID 1432974ノート

反応式

HRID 1432974 の反応式
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][NH:16][CH:15]([CH2:19][CH3:20])[C:14]3=[O:21])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:22][C:23]1[S:27][C:26](/[CH:28]=[CH:29]/[C:30](O)=[O:31])=[CH:25][CH:24]=1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:30](=[O:31])[CH:29]=[CH:28][C:26]4[S:27][C:23]([Cl:22])=[CH:24][CH:25]=4)[C@@H:15]([CH2:19][CH3:20])[C:14]3=[O:21])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 1310045069193-39-1HCID 179851971-(4-Aminoquinazoline-7-ylmethyl)-3-ethylpiperazine-2-one

生成物 1

HCID 54335788HCID 54335788、化合物

実験手順

The title compound is prepared as described in EXAMPLE 123, using 1-(4-aminoquinazoline-7-ylmethyl)-3-ethyl-piperazine-2-one, EXAMPLE 77 and 3-(5-chloro-thiophen-2-yl)-(E)-acrylic acid, EXAMPLE 25. 1H NMR(d6-DMSO+1 drop TFA, 300 MHz) δ9.78 (bs, 2H), 8.79 (s, 1H), 8.37 (d, 1H), 7.65 (m, 2H), 7.50 (s, 1H), 7.41 (m, 1H), 7.11 (d, 1H), 6.98 (d, 1H), 4.88 (m, 2H), 4.60 (m, 1H), 4.31 (m, 1H), 3.52 (m, 1H), 3.30 (m, 2H), 1.96 (m, 2H), 0.88 (m, 3H). MS (ion spray), m/z, (M+H)=456, 458 (Cl pattern). Elemental analysis, cal C22H22ClN5O2S.1.5C2HF3O2% C=47.89, % H=3.78, % N=11.17; found % C=47.34, % H=4.00, % N=11.12.

出典と根拠

ORDレコード
ord-173988e2e8b84edc83137ba5890d8a3a
出典データセット
uspto-grants-2009_11
特許番号
US07612075B2

反応ノート

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