4-(Trifluoromethyl)benzylamine → HCID 178506180、化合物

HRID 1433199ノート

反応式

HRID 1433199 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7](Cl)=[N:8][C:4]=2[CH:3]=1.[F:12][C:13]([F:23])([F:22])[C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=1>>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7]([NH:19][CH2:18][C:17]3[CH:16]=[CH:15][C:14]([C:13]([F:12])([F:22])[F:23])=[CH:21][CH:20]=3)=[N:8][C:4]=2[CH:3]=1

参加物

3

反応物 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 178478307HCID 178478307、化合物

生成物 1

HCID 178506180HCID 178506180、化合物収率 63%

反応条件

温度
200 °C

実験手順

A mixture of 5-bromo-2-chloro-1H-benzoimidazole (0.100 g, 0.432 mmol) and 4-trifluoromethyl-benzylamine (0.8 mL) was heated in a microwave apparatus at 200° C. for 1 hour. The reaction mixture was cooled, and purified by chromatography (silica, hexanes: EtOAc, 1:1) to afford the title product as a white solid (0.101 g, 63%).

後処理

  1. temperatureThe reaction mixture was cooled
  2. custompurified by chromatography (silica, hexanes: EtOAc, 1:1)

出典と根拠

ORDレコード
ord-218d1f6dcce94105887ebbd8e7d09988
出典データセット
uspto-grants-2009_11
特許番号
US07612211B2

反応ノート

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